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These conditions of loading go beyond the capacity of the endogenous antioxidant defense system, with clear depletion of glutathione activity, which is overwhelmed by massive generation of ROS from cellular Fe 2+ engaged in Fenton reactions/HaberWeiss reactions 2,3
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These bifunctional molecules link a ligand for the target protein to a ligand recruiting an E3 ubiquitin ligase, such as VHL, MDM2, CRBN, or IAPs
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Branched-chain amino acids enhance the cognitive recovery of patients with severe traumatic brain injury
