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Int J Mol Sci 19:711

The methotrexate liver toxicity was more aggressive when combined with mildronate and reversed to normal control levels upon supplementation with carnitine, emphasizing its magical protective effect

Erastin inhibits system Xc to lower GSH, reverses the Warburg effect, and thus primes mitochondria to amplify copper-mediated cuproptosis, culminating in irreversible mitochondrial damage