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While we cannot completely exclude COX inhibition as one of the mechanisms of p-aminophenol or AM404 inhibitory activity, it appears not to be the primary mechanism by which these compounds reduce microglial activation

HCA appears to slows an enzyme called citrate lyase, which your body uses to make fat

doi: 10.1093/ajcn/77.4.1001S

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DOI: 10.1016/j.peptides.2024.171149

Notably, fosgonimetons Phase 2/3 LIFT-AD trial in mild-to-moderate Alzheimers disease missed its primary endpoint in topline results released in 2023