The oral melanotic macule is a flat brown mucosal discoloration produced by focal increase in melanin deposition or a concomitant increase in the number of melanocytes
Additionally, GLP-1 medications are associated with gastrointestinal side effectsincluding nausea, vomiting, diarrhoea, and constipationwhich can affect nutritional intake and hydration status
Identification of the dose administered
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Based on the proposed theory, it is postulated that the primary etiological factor underlying hypertension, ageing, atherosclerosis, stroke, venous thrombosis, obesity, heart disease, diabetes, and intimal hyperplasia is the inflammatory response exhibited by endothelial cells (85)
The initial stage can occur already in the intestine due to the spontaneous interaction between electrophilic carbon in the SFN molecule and nucleophilic thiol group of GSH, forming the SFN-GSH conjugate