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Vaping can be a gateway into smoking, Durkin said

More than 4,000 chemicals have been identified in tobacco smoke of which at least 43 are known to cause cancer in humans and animals

This is a warning for all practitioners, as antibiotics may be overused in advanced skin tumors. Though limited by its retrospective design, the study reinforces a call for prospective trials examining microbiota modulation strategiessuch as antibiotic stewardship, bacterial profiling, or even microbiome restorationto enhance ICI outcomes

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