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This is particularly relevant in South Africa, where the illicit tobacco market is estimated to account for as much as 75% of the entire industry

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Histoplasmosis, a fungal infection, is another common cause

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Because survey respondents were asked about their use of cigarettes and e-cigarettes simultaneously and retrospectively, it is unclear how patterns of use changed over the life course and how these reported symptoms may or may not lead to medical diagnosis of disease in the long-term