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Cigarette tobacco has been supercharged with thousands of chemicals to increase the nicotine content and make it more addictive - a process which also greatly increases the harm

Haney M, Ward AS, Comer SD, Foltin RW, Fischman MW (1999b)

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DISCUSSION To better understand the metabolic differences in smokers who smoke cigarettes with low and high nicotine content, untargeted metabolomics and bioinformatics analyses were used to assess the metabolomic profiles of urine samples

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