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42 Without regulation or control of the sale of these products, consumers must rely on safety advice that they receive at the point of sale or on the Internet, which is inconsistent at best

In particular, a 2011 study published in the journal Science showed that nicotine enhances the activity of pro-opiomelanocortin (POMC) neurons in the hypothalamus, which are known to reduce appetite

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If you like, you can switch off the fuzz effect for a clean sound