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These include genetic susceptibility, such as polymorphisms in major histocompatibility complex (MHC) genes and specific variants in the p53 gene implicated in HPV persistence and clearance, as well as genetic diversity among HPV types, co-infection with multiple HPV strains, reinfection frequency, hormonal influences, and the host immune response

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doi: 10.1016/j.ccell.2022.08.012 267 Cavallo-MedvedDMoinKSloaneB