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Nicotine is the notable ingredient in all tobacco products, including cigarettes, that causes physical, mental, and behavioral dependence and makes it hard to quit smoking

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A higher historical smoking prevalence and diagnostic capacity in areas with a high SDI, coupled with an aging population, may lead to a higher burden ( Smoking was the largest contributor to ASR-DALYs (1603.98/100,000), far exceeding those of secondhand smoke (85.49/100,000) and chewing tobacco (50.52/100,000), underscoring its public health impact