Date of publication December 7, 2022 Keyword benefits increased sample size discovery diversity transcriptome-wide association study scores predictive power variants population global ancestry polygenic risk scores heritable behavior genetic diversity samples individuals function gene discovery size risk tobacco sample size architecture diverse ancestry substances fine-mapping prediction effect size use death resolution polygenic risk risk score loci genome-wide association studies genetic architecture study behavior dimensions injury1 effect ancestry increased risk power polygenic prediction association studies cline alcohol use fine-mapping resolution disease alcohol identification locus identification globe DOI Identifier DOI: PMCID: PMC9771818 Dimensions ID: pub.1153437461 PMID: 36477530 Resource type Article Rights statement In Copyright License Attribution 4.0 International Journal title Nature Journal volume 612 Journal issue 7941 Page start 720 Page end 724 Version Publisher Funder Canadian Institutes of Health Research Cancer Research UK Wellcome Trust National Institute of Neurological Disorders and Stroke Central Norway Regional Health Authority National Cancer Institute Medical Research Council Office of the Director National Institute on Drug Abuse National Institute on Alcohol Abuse and Alcoholism National Institute of Environmental Health Sciences National Heart Lung and Blood Institute National Institute of General Medical Sciences National Institute of Biomedical Imaging and Bioengineering National Institute of Diabetes and Digestive and Kidney Diseases National Human Genome Research Institute ISSN 1476-4687 0028-0836 Publisher Springer Nature Relations Parents: In Collection: This work has no parents.

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Smoke exposure can also lead to an increased risk of heart disease and other harmful heart conditions