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There remains a lack of convincing data on the chronic cannabis smoke inhalation and development of alveolar damage [151] and remains equivocal owing in part to varying definitions of joint years, variation in usage patterns between cannabis and tobacco smokers, changes in the size and strength of cannabis cigarettes (joints) over time and control for concomitant tobacco use

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44 In addition, in BC xenograft mouse models, a reduction in tumor growth rate and metastasis, combined with decreased TAM infiltration, was observed when they were treated with macrophage-targeting chemotherapy (trabectedin) or CSF1 inhibitors, which highlighted a potential therapeutic opportunity