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Simmen et al., 2023), led to increased inflammation and/or adiposity from increased NADPH oxidase activity and lipid synthesis (Jamerson and Bradshaw, 2024), therefore limiting the potential utility of therapies that globally increase ME1 activity to stabilize the cytoplasmic [NADPH]/[NADP + ] and [NAD + ]/[NADH] with aging

There are clinical trials and there are anecdotal reports, but they are not substantial

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Our observation of accumulation of L-carnitine in the stationary phase is consistent with release of TML by protein degradation, which primarily occurs in this growth phase