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These pharmacokinetic characteristics reflect ACs poor gastrointestinal absorption, high first-pass metabolism, and possible efflux by transporters such as P-gp, which together significantly limit its oral bioavailability and therapeutic translation

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mild redness may occur temporarily

Impairment of apoptotic cell engulfment by pyocyanin, a toxic metabolite of Pseudomonas aeruginosa

Furthermore, it is thought that green tea has some 5--reductase inhibiting properties