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Cu 2+ consumes GSH and down-regulates GPX4 to provoke ferroptosis, whereas Cu + -mediated oligomerization of DLAT drives cuproptosis, accompanied by FDX1 down-regulation

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Medications such as clonidine and guanfacine target alpha-2 adrenergic receptors in the brain [45], helping regulate neurotransmitter release and alleviating ADHD symptoms by reducing hyperactivity and impulsivity through their calming effects on the central nervous system

It was removed from Category 2 on April 23, 2026 and is on the July 23, 2026 PCAC agenda

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Table 2 Baseline characteristics of CVOTs involving GLP-1 receptor agonists and key findings