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Glucose stimulated insulin secretion (GSIS) Culture medium containing Exe4 was obtained from Hepa1-6 cells and HepG2 cells transfected with a plasmid expressing NGF-FCS2-Exe4 (referred to as scExe4_Hepa1-6 and scExe4_HepG2, respectively)

This remains theoretical, but it represents one of the more scientifically plausible mechanisms by which tirzepatide might influence autoimmune outcomes beyond simple weight reduction

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Chu ZL, Carroll C, Alfonso J et al (2008) A role for intestinal endocrine cell-expressed GPR119 in glycemic control by enhancing GLP-1 and GIP release

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At discharge, 60.31% remained with an Rm of 4-6, reflecting limitations in recovery