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Unlike typical obesity, lipedema fat does not respond significantly to dieting or exercise

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Diabetic Nephropathy Diabetic nephropathy (DN), also known as diabetic kidney disease (DKD) [36,37,38], is a major cause of CKD and end-stage kidney failure in diabetic patients [39,40,41]

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FIGURE 2 The accumulation of methylmalonic acid (MMA) and Hcy because of these disruptions leads to oxidative damage and impaired methylation