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Type 2 DM Pathophysiology: T2DM involves the interplay of insulin resistance (primarily at skeletal muscle, liver, and adipose tissue) and progressive beta-cell secretory failure

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NAFLD refers to a group of liver diseases that includes simple steatosis (benign fatty infiltration), non-alcoholic steatohepatitis (NASH) (fatty infiltration plus inflammation), fibrosis, and cirrhosis, which occasionally progresses to hepatocellular carcinoma 4

It is a fundamental metabolic regulator

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