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Specifically, it has been reported that H 2 O 2 -dependent inactivation of autophagy-related gene-4 ( ATG4 ) increases LC3-associated autophagosomes and that ATM-mediated oxidation of AMP-activated protein kinase (AMPK) inhibits mammalian target of rapamycin 1 (TORC1), a pivotal negative regulator of autophagy 115,116,117 (Fig
doi: 10.1016/j.jaci.2020.12.623 16 DecoutAKatzJDVenkatramanSAblasserA
The external 2-phenylpropionate moiety is stabilized by stacking with Y145 1.40b and hydrophobic interactions with L142 1.37b , while the carboxylic acid forms a salt bridge with K202 2.72b
1 - Agence franaise de scurit sanitaire des aliments (Afssa)
Nazary-Vannani A, Ghaedi E, Mousavi SM, Teymouri A, Rahmani J, Varkaneh HK