Common GI side effects (affecting more than 1 in 10 people) according to the SmPC: Nausea : The most frequent side effect, reported in approximately 44% of patients in clinical trials, usually most pronounced during the first few weeks and with dose increases Diarrhoea : Affects roughly 30% of users, typically mild to moderate and transient Vomiting : Occurs in about 24% of patients, often associated with eating too quickly or consuming large portions Constipation : Reported in approximately 24% of users, which may require dietary modification or occasional laxative use Abdominal pain or discomfort : Affects around 20% of patients, usually described as cramping or bloating Dyspepsia and reflux : Indigestion and heartburn occur in approximately 9% of users Less common but significant GI effects : Delayed gastric emptying : Whilst this is the intended pharmacological effect, in some cases it can cause persistent nausea, vomiting, and inability to tolerate food Pancreatitis : Has been reported in clinical trials and post-marketing
NewHormonal & Mens Health Neuroscience 2 July 2026 Dihexa & Low Testosterone Brain Fog: Low-T, Andropause & TRT (2026 UK Review) Can a synaptogenic peptide clear low testosterone or andropause brain fog
Similar content being viewed by others Introduction According to the statistics of the International Diabetes Federation, the global prevalence of diabetes among the age group of 2079 years was 9.3% in 2019
Gastrointestinal adverse effects are the most commonly reported side effects associated with tirzepatide therapy
Always follow your healthcare providers advice when it comes to alcohol use
Please note that due to the Mounjaro shortage, specific dose strengths, particularly starter doses, may be unavailable
