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It is lipophilic and the acidic environment of the gastrointestinal tract can deactivate it, leading to its reduced bioavailability [144]

The phentermine label states that tolerance to the anorectic effect usually develops within a few weeks and that the drug should be discontinued if that happens, explicitly warning that the recommended dose should not be exceeded

For participants taking SGLT2 inhibitors, there were nonsignificant reductions in CV endpoints and all-cause death for the semaglutide vs

Myth: Early dosing leads to tolerance and reduced effectiveness Also false

A number of other therapies are contraindicated in this patient population

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