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Sulforaphane (66) is a potent inducer of the Nrf2 transcription factor, has bloodbrain barrier penetration (67), and might expand the size of the glutathione reservoir by our observation that it increases expression of GCL, the rate-limiting step in glutathione biogenesis
doi: 10.1080/15563650.2020.1788056.) My own view is there will never be a well-done RCT that settles this question, given the imposing costs and logistics required, as well as the relatively few patients who would be eligible
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Molecules 26 , 6807 (2021)
Homogentisic acid serves as an important tool molecule for investigating the mechanisms of diseases including ochronosis, secondary amyloidosis, Alzheimer's disease, and colorectal cancer
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