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SARS-CoV-2-infected patients with COVID-19 disease show alterations in the glucoseinsulin axis leading to hyperglycemia, hyperinsulinemia and insulin resistance, increased oxidative/nitrosative stress, and significantly decreased vitamin D, thiols, total-antioxidant-capacity, GSH and selenium (Soto et al., 2022)

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Phase 3 results, which use larger patient populations and longer follow-up periods, came in somewhat lower

Subcutaneous injection requires bacteriostatic water, proper mixing technique, and either syringes or an injection pen