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The first signs of B12 deficiency include persistent fatigue, weakness, lightheadedness, pale skin, tingling or numbness in the hands and feet, difficulty concentrating, and mood changes like irritability or mild depression

It causes a narrowing in the spaces encompassing the neurovascular structures of the spine, leading to the characteristic clinical syndrome of buttock and bilateral lower extremity pain that may include the lower back

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stable up to 24 months [4]