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Propensity scorematched cohorts were built to compare (1) 4606 patients who received GLP-1 receptor agonistSGLT-2 inhibitor combination with 18,424 who received only GLP-1 receptor agonist, and (2) 5368 patients who received this combination with 21,472 who received only SGLT-2 inhibitors

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The FDA agreed in September 2025 to accept lean mass and fat mass as co-primary endpoints, which could set a regulatory precedent for the entire category