MW 1419 Da) originally isolated from human gastric juice [1]
~5-fold potency at GIPR relative to native GIP
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Reverse-phase HPLC (C18 column, acetonitrile/TFA gradient) establishes chromatographic purity with UV 220 nm detection, minimum threshold of 98%, individual impurities quantified below 0.5%
A 2A R antagonists generally have higher molecular weights and are difficult to synthesize due to the complexity of structures, poor water solubility, and furan groups that preclude replacement by classic chemistry [63]