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In general, diuretics can worsen LVH, glucose tolerance, and lipid abnormalities
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Health Psychol Res 11:81043 Stahl SM et al (2004) A review of the neuropharmacology of bupropion, a dual norepinephrine and dopamine reuptake inhibitor
For instance, survodutide achieved the improvement of MASH without worsening of fibrosis in up to 62% of participants versus 14% with placebo, and significantly reduced liver fat content measured by MRI-PDFF in the phase 2 trial in patients with MASH [82], further reinforcing the therapeutic relevance of dual GLP-1/GCGR engagement in MASH
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