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In the CNS, GLP1 is synthesised by a relatively small population of a few thousand neurons primarily located within the lower brainstem of vertebrates, in the nucleus tractus solitarii (NTS) and in the adjacent intermediate reticular nucleus (IRT) (Larsen et al., 1997

An apparent paradox is that whereas GLP-1 increases glucose-stimulated insulin secretion in the isolated pancreas fulfilling the definition of an incretin but it lowers insulin secretion in physiologically relevant conditions [6, 10, 18]

Slows Stomach Emptying Food remains in the stomach longer, prolonging satiety and reducing the urge to snack

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GLP-1, or glucagon-like peptide-1, is a hormone naturally produced in your gut that plays a crucial role in regulating appetite and metabolism

These medications, including semaglutides like Ozempic, are commonly used in the treatment of type 2 diabetes and obesity