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De Micheli, A
T.MortazaviS
Prospects In recent years, numerous studies have commenced exploring the interplay between ferroptosis, immune cells, and autoimmune diseases, accentuating the dual role of ferroptosis in pathology
Cancers 12 , 3810 (2020)
Inactivation of DHODH in cancer cells with low GPX4 expression significantly increased intracellular lipid peroxidation, while in cancer cells with high GPX4 expression, DHODH inactivation synergized with inducers to enhance ferroptosis
Another research including 111 families, demonstrated that deficient MTHFR enzyme activity in pregnant women was related to the A1298C variant, which was associated with a higher risk of schizophrenia in the offsprings 60
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