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Remarkably, two major regulators of these pathways of phenotypic transition are somehow related to cholesterol metabolism, including APOE, involved in cholesterol extracellular transport, and TREM2, which has been recently shown to regulate the intracellular movement of cholesterol in microglia [42]

Increased GSH synthesis neutralizes reactive oxygen and nitrogen species and regulates zinc homeostasis promoting neuroprotection after ischemia/reperfusion (162)

In future work, the team plans to expand beyond Reddit and English-language discussions to confirm whether the same symptoms appear across different social media platforms and populations

10.1007/s12975-014-0365-7 162

These results suggest that nutraceuticals can complement traditional therapies

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