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3.1.5 Genetic and epigenetic regulation Genetic and epigenetic mechanisms regulate gene expression through reversible chemical modifications and non-coding RNAs without altering the underlying DNA sequence, playing a pivotal role in the development of drug resistance in gastrointestinal (GI) tumors

In addition, SIRT1 reduces oxidative stress and inflammation by inhibiting the nuclear factor kappa B (NF-B) signaling pathway, resulting in decreased production of inflammatory cytokines, including IL-1, interleukin-6 (IL-6), tumor necrosis factor (TNF-), and ROS (133135)

PLoS One 14:e214250

2.3 Drugs CB-839 (0.1-100 M