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While mostly considered weight loss medications, GLP-1s like Semaglutide also show significant benefit in reducing the risk of heart attack, stroke, and cardiovascular death in high-risk patients

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Tirzepatide is a compounded once-weekly injectable medication that mimics two natural hormones: GLP-1 and GIP

This disrupts the structural integrity of the intestinal epithelial barrier, reduces the expression of tight junction proteins (such as occludin, claudin and ZO-1) and increases intestinal barrier permeability 51

The injection site selection and technique principles mirror those for semaglutide and tirzepatide