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These conditions commonly resist conventional interventions that only superficially address pigment accumulation rather than the underlying melanogenic mechanisms

p = 0.0056]

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Therefore, it is likely that mechanisms of protein S -glutathionylation within the cells involves reaction of the critical cysteine on protein or GSH with a corresponding oxidized derivative such as S-nitrosyl ( S -NO), sulfenic acid ( S -OH), thiyl radical ( S )