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doi: 10.3389/fphar.2023.1185850 Received 14 March 2023 Accepted 19 June 2023 Published 27 June 2023 Volume 14 - 2023 Edited by George P
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The first available amylin agonist was pramlintide, which is already approved for treatment of type 1 and type 2 diabetes in conjunction with insulin [4]
Published in Nature Communications , the study reveals that RPN2, a subunit of the proteasomal 19S regulatory particle, contains a previously unrecognized K11-specific binding site
Lane 1: HEK-293 cell lysate (20 g/Lane) Lane 2: HepG2 cell lysate (20 g/Lane) Lane 3: SH-SY5Y cell lysate (20 g/Lane) Lane 4: HT-29 cell lysate (20 g/Lane) Lane 5: Human liver tissue lysate (40 g/Lane) Lane 6: Human kidney tissue lysate (40 g/Lane) Predicted band size: 22 kDa Observed band size: 22 kDa Exposure time: 24 seconds
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