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Due to its multifaceted biological activity, it is a staple in advanced comparative studies involving the regeneration of skeletal muscle fibers, tendons, and ligaments

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1 StatPearls

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In addition, HSF1 may act directly in proteostasis without upregulating HSP70, as there is evidence of HSF1 binding to defective proteins such as amyloid oligomers (Tang et al., 2020)