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While it is perhaps somewhat surprising that no group differences in metabolite concentrations were found, either for GABA (as has been shown before) or for GSH, we note that autism is an extremely heterogeneous condition, and that group differences, if present, may be small and relatively uninformative in understanding the broader autism phenotype(Loth et al., 2021)

For most people, diarrhea caused by glutathione is temporary and should resolve within a day or two of reducing the dose or stopping the supplement

Gradual improvements in metabolic markers align with expected treatment effects, while acute changesparticularly in pancreatic, gallbladder, or kidney functionwarrant careful evaluation

Sterile preparation and proper storage should always be followed

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