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Some studies suggest that DHODH activity is particularly crucial under conditions of GSH depletion, while others propose that the pathway's significance varies according to tissue type and metabolic state (80, 81)

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This agrees with previous observations that indicate p53 mutants with the P72 SNP have a greater propensity to retain WT-like p53 activity in comparison to those with the R72 SNP [15, 25, 30,31,32]

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