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Whilst mTORC1 activates S6 kinase, which phosphorylates serine residues on IRS which in turn uncouples IRS from the receptor and its substrates, mTORC2 can reactivate this signalling

Extra fat cells act like mini chemical factories, releasing hormones and inflammatory messengers called cytokines, such as interleukin-6 (IL-6), Tumor necrosis factor alpha (TNF-alpha), interleukin-17 (IL-17), and others

Although emerging evidence supports the potential benefits of these interventions, current data remain inconclusive, and individualized treatment approaches are necessary

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Oral GLP-1 Race Heats Up Novo Nordisk and CORXEL Pharmaceuticals both made major movesNovo with FDA approval of oral Wegovy and Corxel with a $287M Series D to advance its oral GLP-1 candidatesignaling strong demand for non-injectable, scalable obesity therapies