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Pharmacological Treatment of Obesity: A Review (2011)

Gastrointestinal adverse events in all treatment groups were more common among women than men, but rates of premature treatment discontinuation were similar for both genders

Under DSHEA, supplements are not subject to FDA pre-market approval for safety or efficacy before going to market - which is categorically different from the FDA's drug approval process

Participants taking the highest dose (15 mg) lost an average of 22.5% of their body weight over 72 weeks, compared to 2.4% with placebo

References Fatima MT, Ahmed I, Fakhro KA, Akil ASA

Approximately 25% of total weight loss typically originates from fat-free mass, with skeletal muscle comprising about half of this component [29]