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Who Might Benefit Tirzepatide may be most relevant for arthritis patients who: Have a BMI of 30 or above with symptomatic knee or hip osteoarthritis Have been told they need joint replacement surgery but want to try weight loss first Have both type 2 diabetes and inflammatory arthritis Have failed to lose enough weight through diet and exercise alone to meaningfully reduce joint symptoms Have improved CRP or other inflammatory markers alongside their joint disease Are looking for a medication that addresses multiple metabolic and inflammatory concerns simultaneously Tirzepatide isn't a direct treatment for arthritis and shouldn't replace disease-modifying therapies for rheumatoid arthritis or other autoimmune joint conditions

Semaglutide is generally less expensive, but cost depends on insurance coverage, manufacturer programs, and whether you qualify for assistance

As we age, our skin naturally loses elasticity and becomes thinner, making it less likely to conform to body changes

Constipation is underappreciated relative to nausea

Others experience some weight regain, particularly if previous eating patterns resume

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