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The applicant further opined that, although not explicitly stated, the paper presumably calculated the sample size based on the primary endpoint of stent removal, not to detect any clinical differences and, while Johnson et al

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Given the lack of dose proportionality, the exposure and the clinical response predicted in the current simulations represent the best-case scenario for the SL formulation

AMY, amylin analogue

Early signs may be mild, but they can get worse if not treated