You do not need dramatic weight loss as an outcome
As body weight decreases, the body's total energy expenditure declinesnot only because there is less mass to maintain, but also because metabolic rate may decrease beyond what would be predicted by weight loss alone
For patients who are unsure if GLP-1s are right for them, that lack of flexibility can make Hers feel like a gamble
In combination with intensive behavioral therapy for weight loss, individuals (total n=611) in another study (note: funded by Novo-Nordisk) on semaglutide lost 16% of their body weight compared to 5.7% in the placebo control group
Your doctor may ask: Did you lose weight but then regain it
In the SURMOUNT clinical trial program for obesity, participants achieved average weight loss of 15-21% of body weight depending on dose, significantly exceeding results with diet and exercise alone or other available pharmacotherapies