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Mechanistic links between obesity, insulin, and cancer

In keeping with the reduced capacity of homocysteine-exposed endothelial cells to inhibit platelet aggregation, Lentz and collaborators demonstrated, using experimental hyperhomocysteinemia (induced by a diet depleted of folate, high in methionine, and choline-free) that the endothelial-dependent vasodilation is impaired in hyperhomocysteinemic primates

5-Amino-1MQ selectively blocks NNMT, preventing methyl-group transfer and, in research models, helping preserve SAM and NAD availability

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These nutrients help maintain healthy testosterone levels (which women also produce in smaller amounts), while supporting mood, focus, and stamina

Science 313 , 11371140 (2006)