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US: Cleveland Clinic Foundation

Compound 3 (VCT220) showed improved oral PK versus PF-06882961 (danuglipron), with ~21-fold higher Cmax and ~5.8-fold higher AUC in rats at 10 mg/kg, and 51% oral bioavailability in monkeys versus 8%

Provides an antioxidant that helps protect against oxidative stress

TB-500 continues organizing collagen fiber architecture, shifting the ratio from immature type III collagen (scar tissue) to mature type I collagen (functional tissue)

Regulated expression and function of the GABA B receptor in human pancreatic cell line and islets

During the clinical trial, the observed side effects were mainly gastrointestinal, such as nausea and vomiting