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The role of matrix metalloproteinases in osteoarthritis and possible matrix metalloproteinases targeted treatments Pathogenesis of osteoarthritis Pathologic changes that occur in OA affect the whole joint and include degradation of the articular cartilage, variable degrees of synovial inflammation, thickening of the subchondral bone, or, in other words, remodeling, hypertrophy of the joint capsule, and osteophyte formation