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However, transgenic Apoe -/- mice overexpressing the entire gene cluster of PON genes (PON-1, -2, -3) were not further protected compared to Apoe -/- mice with transgenic expression of PON-1 or PON-3 alone (435), suggesting these effects are redundant rather than additive

Some possible, more severe side effects include pancreatitis and thyroid tumors, among other medical conditions

The results stunned researchers: in trials, people lost up to 22.5% of their body weight, figures that made even semaglutide look modest

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