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Deeper understanding of these mechanisms may revolutionize the therapeutics of obesity, diabetes, and related disorders through interventions that harmonize sensory experience with metabolic needs

First we assessed proteolytically active proteasome subunits MECL1 , LMP2 and LMP7 required for assembly of the 20 S proteasome, protein degradation and amino acid recycling 25 , finding IGF-induced MECL1 downregulation in DU145 cells only and LMP2 downregulation in both DU145 and 22RV1 (Supplementary Figure S2A)

Mitophagy serves as the critical defensive mechanism preventing these mitochondrial insults from overwhelming neurons

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Casciani CU, Caruso U, Cravotto E, and et al

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