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Ida, T., Sawa, T., Ihara, H., Tsuchiya, Y., Watanabe, Y., Kumagai, Y

This spiral of damage will continue unless the free radical is neutralised

Birch DJS, Imhof RE (2002)

The more stressed you are, the more hydrogen peroxide your body makes and the more glutathione you need

Figure 4 Molecular alterations in a target protein can also result in acquired drug resistance, such as crizotinib resistance in lung adenocarcinoma, which occurs due to a secondary mutation (G2032R) in the reactive oxygen species (ROS) proto-oncogene 1 (ROS1) kinase domain ( MET ) ( EGFR -mutant cancer cell lines revealed that gefitinib resistance was associated with an oncogenic mutation in phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA)