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One very recent study of a TREM2 agonistic antibody in the cuprizone model reported enhanced myelin debris uptake and degradation, together with improved remyelination (Cignarella et al., Another approach could involve targeting lipid metabolism, as the uptake of too much cholesterol-rich myelin debris converts microglia into cells with a proinflammatory profile
Philp D, Kleinman HK
To evaluate biomarkers of oxidative stress and damage by high-performance liquid chro- matography (HPLC), approximately 200 mg of tissue was minced and homogenized in 500 ml of ice-cold phosphate- buffered saline
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Zhao W, Michalik D, Ferguson S, Hofstetter W , Lematre J, von Rechenberg B, Bowen P
Funding This work was supported by the University of Zagreb, Zagreb, Croatia (Grant BM 099)
