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Therefore, the use of new technological advances such as single cell RNA-seq can shed new light on the GLP-1RA-dependent and independent effects and targets in animal models and humans [177]

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JooEHaradaNYamaneSFukushimaTTauraDIwasakiKet al

For cardiomyopathy, GLP-1RAs improve mitochondrial function via regulating autophagy and inflammatory signaling, as well as not only mediate the inhibition of myocardial apoptosis, but also improve cardiac energy metabolism

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However, the physiological changes they cause significant dehydration, rapid weight loss, and altered thermoregulation raise UV risk indirectly